Tamás Bálint Csont;Attila Kis-Tamás;Gábor Medgyes;László Kovács;Sándor Cseh;György Dor;Péter Ferdinandy;Krisztina Kedvesné Kupai;Zsolt Lörincz;Dénes Kónya;Ferenc Tamás Takács;Csaba Csonka;István Hajdú
发明人:
Péter Ferdinandy,Tamás Bálint Csont,Csaba Csonka,Krisztina Kedvesné Kupai,László Kovács,Attila Kis-Tamás,Ferenc Tamás Takács,Dénes Kónya,Gábor Medgyes,Sándor Cseh,István Hajdú,Zsolt Lörincz,György Dor
申请号：
US13990684
公开号：
US09487462B2
申请日:
2011.12.19
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Compounds of general formula (I), salts or solvates thereof and pharmaceutical compositions containing same:wherein Z is N or CH or the Z(R1) part is replaced with a covalent bond, m and n is 0, 1, 2 or 3； HET is heteroaryl； X is CF3, halogen, CO-heterocyclyl, COOR3 or CONHR3； R1 is H, (CH2)o-aryl, (CH2)p-heteroaryl, (CH2)q-biphenyl； C(O)—R5； S(O)2—R6； R2 is H, aryl, heteroaryl, Y—(CH2)r-aryl, Y—(CH2)s-heteroaryl, where some of the above substituents may be substituted； Y is O or S； with the exclusion of the compound where HET is 1,3-thiazol, X is COOH, R1 is 4-fluorophenyl and R2 is benzyloxy. The invention also relates to the use of a compound of general formula (I), salts or solvates thereof for the use in the prevention or treatment of diseases where the activation of MMPs is involved in the pathomechanism. In this aspect the use of the above excluded compound is also inventive.
