Richard Chesworth,Oscar Miguel Moradei,Gideon Shapiro,Lei Jin,Robert E. Babine
申请号：
US15835758
公开号：
US10118931B2
申请日:
2017.12.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are compounds of Formula (I):and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein X, R1, R1a, R2a, R2b, R2c, R2d, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula:wherein L2, R13, G8, G10, G11, and G12 are as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.
