The invention relates to new compounds with low cytotoxicity for blocking ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of treating disorders including, but not limited to, cancers, neurodegenerative diseases, inflammatory disorders and autoimmune disorders and metabolic disorders.本發明係關於用於阻斷疾病中泛素化-蛋白酶體系統之具有低細胞毒性之新穎化合物。因此,該等化合物可用於治療包括(但不限於)癌症、神經退化疾病、發炎病症及自體免疫病症及代謝失調之病症之治療。
