The invention relates to new compounds with low cytotoxicity for blocking the ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, cancers, neurodegenerative diseases, inflammatory disorders, autoimmune disorders and metabolic disorders.本發明係關於用於阻斷疾病之泛素化-蛋白酶體系統之具有低細胞毒性之新穎化合物。因此,該等化合物可用於治療包括(但不限於)癌症、神經退化疾病、發炎病症、自體免疫病症及代謝失調之病症。