The present invention provides the compounds for being suitable for proteasome inhibitor. The present invention also provides the Pharmaceutical composition containing the compounds of this invention and the methods for treating various diseases using the composition.本發明提供適用作蛋白酶體抑制劑的新穎化合物。本發明還提供含有本發明化合物的藥用組合物以及使用所述組合物治療各種疾病的方法。