CAULFIELD, THOMAS J.,汤玛士,湯瑪士,CLEMENS, JENNIFER W.,克莱曼,克萊曼,FRANCIS, ROBERT S.,罗伯特,羅伯特,FREED, BRIAN S.,布莱恩,布萊恩,JOHN, STANLY,史丹利,LE, TIEU-BINH,李泰宾,李泰賓,PEDGRIFT, BRIAN,沛黎特,RAMOS, ANTONIO D.,罗摩斯,羅摩
申请号：
TW097120661
公开号：
TWI446905B
申请日:
2008.06.04
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention relates to novel compounds of the formula I :wherein in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, wherein the substituents are as described herein. The inventive compounds have CXCR5 inhibitory activity are particularly useful in treating or preventing various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, lupus, Crohn's Disease, associated with the modulation of the human CXCR5 receptor.本發明係關於新穎的式I化合物：其中，任何其之立體異構型式或任何比例之立體異構型式之混合物，或生理上可接受的鹽，其中該取代基係如本文中所述者。該發明之化合物具有CXCR5抑制活性且特別有用於治療或預防各種發炎性疾病，例如，類風濕性關節炎，多發性硬化，狼瘡，節段性迴腸炎，合併著人類CXCR5受體之調節。
