A subject of the present invention is to provide a novel aromatic five- or six-memberd heterocyclic derivative having 4-pyridylalkylthio as a substituent or a salt thereof which is useful as a pharmaceutical. Compound represented by the following general formula ÄIÜ or salts thereof are useful as therapeutic agents for diseases in which angiogenesis or augmentation of vascular permeability is involved. In the formula, ring "A" is a benzene ring or an aromatic five- or six-memberd heterocycle which can be fused with a cycloalkane ring, "B" is alkylene, R<；1>； and R<；2>；, the same or different, are H, OH, substituted or unsubstituted alkoxy and the like, X and Y, the same or different, are group(s) selected from H, halogen, OH, substituted or unsubstituted alkoxy and the like respectively, p is 0, 1 or 2, and q is 0 or 1.本發明提供可作為醫藥有用之具有以4-吡啶烷硫基為取代基之新穎芳香族雜五或六員環衍生物或其鹽為課題。下述一般式〔I〕之化合物或其鹽可作為血管新生或血管透過性亢進參與之疾病之治療劑有用。式中，環A為苯環、或可與環烷環稠合之芳香族五或六員雜環，B為伸烷基、R1及R2可相同或相異，各為H、OH、取代或無取代烷氧基等，X及Y各可相同或相異，各為選自H、鹵素、OH、取代或無取代烷氧基等之1或複數之基、p為0、1或2，q為0或1。；
