Benign pigmented moles of the skin or mycosis pedis or nail fungus can betreated withlocally applicable, in particular topically formulated active ingredients offormula (I), inwhich formula (I) X represents CO, CHOZ or CHNRZ, Z being selected fromhydrogen；straight-chain and branched (C1-C6) alkyl； straight-chain or branched (C2-C6)alkenyl；straight-chain or branched (C2-C6) alkynyl； (C3-C8) cycloalkyl； (C6-C24) aryl；(C7-C24)aralkyl； m- and p-CH2(C6H4)COOM； COR3； CSR3； C(NR6)R3； SOR4； SO2OM；SO2NR7R8； SO2O-artemisinyl； SO2NH-artemisinyl； POR4R5 and PSR4R5； wherein R3isstraight-chain or branched (C1-C6) alkyl； straight-chain or branched (C1-C6)alkoxy；straight-chain or branched (C2-C6) alkenyl； straight-chain or branched (C2-C6)alkynyl；(C3-C8) cycloalkyl； (C6-C24) alkyl； (C1-C10) aryloxy； (C7-C24) aralkyl； -(CH2)n-COOM,with n as an integer of from 1 through 6； or 10.alpha.-dihydroartemisinyl； R4and R5 areselected independently of one another from straight-chain or branched (C1-C6)alkyl；straight-chain or branched (C2-C6) alkenyl； straight-chain or branched (C2-C6)alkynyl；(C3-C8)cycloalkyl； (C6-C24) aryl； (C7-C24) aralkyl； OM； straight-chain orbranched (C1-C6) alkoxy； (C6-C10) aryloxy and NR7R8； R6 is selected from straight-chain orbranched(C1-C6) alkyl； straight-chain or branched (C2-C6) alkenyl； straight-chain orbranched (C2-C6) alkynyl； (C3-C8) cycloalkyl； (C6-C24) aryl and (C7-C24) aralkyl； M ishydrogen or apharmaceutically acceptable cation； and R7 and R8 independently of one anotherarehydrogen or straight-chain or branched (C1-C6) alkyl, or R7 and R8 togetherform a (C4-C6) alkylene bridge； and R is selected from hydrogen and the groups listed forR6 . Thesecompounds are also effective in the prevention of acquired nevus cell nevi.
