Neil R. Cashman,Steven S. Plotkin,William C. Guest
申请号：
US14997951
公开号：
US10475525B2
申请日:
2016.01.18
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A method and system to identify an epitope unique to a misfolded form of a protein is provided. Sets of one or more amino acid residues are selected from a model representing the structure of the protein； the free energy of unfolding of each set is determined； and the epitope is identified from the sets having a total probability of unfolding above a minimum probability or a free energy of unfolding below a minimum energy. In other aspects, the invention provides for the use of epitopes identified by the epitope prediction methods, and related antibodies, to diagnose and treat disease and to screen samples for the presence of such epitopes.
