Disclosed is a preparation method of a jujuba cyclic adenosine monophosphate (Jujuba cAMP) of a pharmaceutical composition for treating at least one of a depression and an anxiety disorder, comprising steps of: (a.) extracting a jujuba for obtaining a first extract having a first jujuba cAMP concentration and (b.) chromatographing the first extract with a macroporous resin containing an aldehyde group for obtaining a second extract having a second jujuba cAMP concentration, wherein the second jujuba cAMP concentration is higher than the first jujuba cAMP concentration.
