Marco A. Coccia;Josephine M. Cardarelli;Jonathan Alexander Terret;David John King;Li-sheng Lu;Chin Pan;Haichun Huang
发明人:
Jonathan Alexander Terret,Li-sheng Lu,David John King,Josephine M. Cardarelli,Chin Pan,Haichun Huang,Marco A. Coccia
申请号：
US12065436
公开号：
US08124738B2
申请日:
2006.09.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.
