Mohan Srinivasan;Alan Korman;Kent B. Thuduim;Edward Halk;Mark Selby;David B. Passmore
发明人:
Alan Korman,Mark Selby,Kent B. Thuduim,Edward Halk,Mohan Srinivasan,David B. Passmore
申请号：
US13553205
公开号：
US08580259B2
申请日:
2012.07.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to BTLA with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for detecting BTLA, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-BTLA antibodies.
