Alan J. Korman,Mark J. Selby,Changyu Wang,Mohan Srinivasan,David B. Passmore,Haichun Huang,Haibin Chen
申请号：
US14796956
公开号：
US09273135B2
申请日:
2015.07.10
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-L1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The disclosure also provides methods for detecting PD-L1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-LI antibodies.
