UNIVERSITY OF VIRGINIA PATENT FOUNDATION;UNIVERSITY OF BIRMINGHAM
发明人:
HUNT, DONALD F.,SHABANOWITZ, JEFFREY,MALAKER, STACY A.,ENGELHARD, VICTOR H.,ZARLING, ANGELA,CUMMINGS, KARA L.,OBENG, REBECCA C.,COBBOLD, MARK
申请号：
CA2883569
公开号：
CA2883569A1
申请日:
2013.09.03
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., cancer, (b) to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.
