UNIVERSITY OF VIRGINIA PATENT FOUNDATION;THE UNIVERSITY OF BIRMINGHAM
发明人:
HUNT, DONALD F.,SHABANOWITZ, JEFFREY,TRANTHAM MYERS, PAISLEY,COBBOLD, MARK,BUTTNER, NICO,MALAKER, STACY ALYSE,PENNY, SARAH
申请号：
CA3023245
公开号：
CA3023245A1
申请日:
2017.05.05
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
A set of target peptides are presented by HLA class I molecules on the surface of hepatocellular carcinoma (HCC) ceils and/or esophageal cancer cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., HCC and/or esophageal cancer, (b) function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.
