The present invention is related to a nucleic acid molecule comprising a double-stranded structure,wherein the double-stranded structure is formed by a first strand and a second strand,wherein the first strand consist of the following nucleotide sequence5 acGaGcUgGaCcAcUgGuCdTSdT 3,and the second strand consists of the following nucleotide sequence5 GAcCaGuGgUcCaGcUcGudTSdT 3,wherein a minor nucleotide indicates that the nucleotide is 2-F modified and an underlined nucleotide indicates that the nucleotide is 2-O-methyl modified andwherein dTSdT indicates that at the 3 end a dinucleotide is attached consisting of two dT nucletoides, wherein said two dTs are covalently linked through a phosphorothioate bond.
