KLAUS GIESE AND JORG KAUFMANN,ELENA FEINSTEIN,KLAUS GIESE AND JORG KAUFMANN,ELENA FEINSTEIN
申请号：
IN1967/DELNP/2007
公开号：
IN258358B
申请日:
2007.03.14
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
A compound having the double-stranded structure: wherein each N and N is a ribonucleotide which may be modified or unmodified in its sugar residue and each of (N)x and (N)y is an oligomer in which each consecutive N or N is joined to the next N or N by a covalent bond wherein each of x and y is an integer between 19 and 40 inclusive wherein each of Z and Z may be present or absent, but if present is dTdT and is covalently attached at the 3 terminus of the strand in which it is present and wherein the sequence of (N)x comprises a first stretch of contiguous nucleotides having any one of the following sequences: AGCUGCAUCAGGUUGGCAC (SEQ ID NO:66) UUCUAGAUGGAAGACCCAG (SEQ ID NO:74) UUGAACAUCAAGUGUAUUC (SEQ ID NO:75) AAAAAUAUUGCAUAGGUCU (SEQ ID NO:77) UACUUGAACAUCAAGUGUA (SEQ ID NO:79) and AACUCAAUGAGCUUCCUGG (SEQ ID NO:91) and the sequence of (N)y comprises a second stretch of contiguous nucleotides, and wherein the double-stranded structure is generated by base-pairing between the first stretch and the second stretch.
