The present disclosure provides antigen-presenting polypeptides, including single-chain antigen-presenting polypeptides and multimeric antigen-presenting polypeptides. The present disclosure provides nucleic acids comprising nucleotide sequences encoding antigen-presenting polypeptides of the present disclosure, as well as cells genetically modified with the nucleic acids. An antigen-presenting polypeptide of the present disclosure is useful for modulating activity of a T cell. Thus, the present disclosure provides methods of modulating activity of a T cell.本發明提供抗原呈現多肽，包括單鏈抗原呈現多肽及多聚體抗原呈現多肽。本發明提供包含編碼本發明之抗原呈現多肽之核苷酸序列的核酸以及經該等核酸基因修飾之細胞。本發明之抗原呈現多肽可用於調節T細胞之活性。因而，本發明提供調節T細胞活性之方法。
