The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell； the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.本發明提供變異體免疫調節多肽及包含該等變異體免疫調節肽之融合多肽。本發明提供T細胞調節性多聚體多肽及包含其之組合物，其中該等T細胞調節性多聚體多肽包含本發明之變異體免疫調節多肽。本發明提供包含編碼該等T細胞調節性多聚體多肽之核苷酸序列之核酸以及包含該等核酸之宿主細胞。本發明提供調節T細胞之活性之方法；該等方法包括使該T細胞與本發明之T細胞調節性多聚體多肽接觸。
