The disclosure provides anti-myostatin antibodies and methods of making and using the same. Nucleic acids encoding the anti-myostatin antibodies and host cells comprising the nucleic acids are also provided. The disclosure also provides polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided.本揭露提供抗肌抑素抗體以及其形成及使用方法。亦提供編碼抗肌抑素抗體的核酸以及包括上述核酸的宿主細胞。本揭露亦提供包含變異Fc區域的多肽以及其形成及使用方法。亦提供編碼多肽的核酸以及包括上述核酸的宿主細胞。