A composition contains Saccharomyces cerevisiae var boulardii and the superoxide dismutase enzyme where the superoxide dismutase enzyme is in gastro protected form is disclosed. The composition is useful as a diet supplement, in the prevention or reduction of the risk of developing metabolic dysfunctions related to obesity and the reduction of weight increase, for the reduction of food intake, for the reduction of body fat accumulation, and for the improvement of the systemic inflammatory condition connected with obesity.
