The alternatively benzothiophene derivative and combinations thereof of property estrogen receptor degradation agent农业专利-农业学术服务平台

发明人:: H．E．伯克斯,M．A．德长斯雷特尔,M．A．德長斯雷特爾,G．何,J．努涅斯,S．波伊克特,C．斯普林格,Y．孙,Y．孫,N．MF．汤姆森,N．MF．湯姆森,G．S．特里亚,G．S．特里亞,B．于,H.E.伯克斯,M.A.德长斯雷特尔,M.A.德長斯雷特爾,G.何,J.努涅斯,S.波伊克特,C.斯普林格,Y.孙,Y.孫,N.MF.汤姆森,N.MF.湯姆森,G.S.特里亚,G.S.特里亞,B.于

摘要：: The present invention relates to compound of formula I: wherein n, m, X, Y1, R1, R2, R3, R4 and R5 are as defined in summary of the invention； The compound can be the effective antagonist and degradation agent of estrogen receptor simultaneously. The present invention also provides method, the pharmaceutical preparation comprising such compound and the methods for controlling disease relevant to abnormal estrogen receptor active or obstacle using such compound and composition that the compounds of this invention is prepared with what.本發明涉及式I化合物：其中n、m、X、Y1、R1、R2、R3、R4和R5如發明概述中所定義；所述化合物能够同時爲雌激素受體的有效拮抗劑和降解劑。本發明還提供用於製備本發明化合物的方法、包含這樣的化合物的藥物製劑和使用這樣的化合物和組合物控制與異常雌激素受體活性相關的疾病或障礙的方法。