作爲選擇性雌激素受體降解子（ＳＥＲＤ）之化合物及組合物农业专利-农业学术服务平台

发明人:: BURKS, HEATHER ELIZABETH,布克斯　席特　伊丽莎白,布克斯　席特　伊麗莎白,DECHANTSREITER, MICHAEL A.,迪查斯特　麦可Ａ,迪查斯特　麥可Ａ,HE, GUO,何　股欧,何　股歐,NUNEZ, JILL,尼斯　吉尔,尼斯　吉爾,PEUKERT, STEFAN,普柯特　史帝芬,SPRINGER, CLAYTON,斯宾那　克雷敦,斯賓那　克雷,布克斯席特伊丽莎白,布克斯席特伊麗莎白,迪查斯特麦可A,迪查斯特麥可A,何股欧,何股歐,尼斯吉尔,尼斯吉爾,普柯特史帝芬,斯宾那克雷敦,斯賓那克雷

摘要：: The present invention relates to compounds of formula I: in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention； capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.本發明係關於式I化合物：其中n、m、X、Y1、R1、R2、R3、R4及R5係於發明內容中定義；該等化合物能夠為雌激素受體之有效拮抗劑與降解子二者。本發明進一步提供製備本發明化合物之製程、包含此等化合物之醫藥製劑及使用此等化合物及組合物管控與異常雌激素受體活性相關之疾病或病症之方法。