The present invention describes a novel oral opioid dispensing system comprised of a mobile Opioid Specific App which utilizes a patient and drug specific drug dispensing algorithm which incorporates the use of digitally captured and patient self-assessment, self-test, and/or self- report, prescription, and dispenser information/values to； (i) control opioid dispensing to improve medication safety, (ii) personalize oral drug therapy, (iii) improve medication effectiveness while avoiding drug mediated side effects, (iv) decreases misuse, abuse, over dosing, under dosing, dependence, addiction, divergence, accidental ingestion, overdose, and deaths, (v) improve disease management, (vi) ensure prescription compliance, and (vii) promotes prescription persistence on a cost-effective real-time basis.
