D'SOUZA, Anne-Marie,AHMED, Mahbub,PULZ, Robert Alexander,ROONEY, Lisa Ann,SMITH, Nichola,TROXLER, Thomas Josef,BALA, Kamlesh Jagdis,BREARLEY, Andrew,DALE, James,PORTER, David,SANDHAM, David Andrew,SHA
申请号：
PE2017000546
公开号：
PE20171443A1
申请日:
2015.05.14
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
1. Refers to a formula (I) carbohydrate derivative or a pharmaceutically acceptable formula salt, wherein R1 is tar (C3-C6) or cyclomethane (C3-C6)；R2 is methyl； R3 is derivative (C6-C10),1. Halogenated derivatives (C6-C10)；There are others It is a selected compound: [n - (2-cyclohexane-1,5-dimethyl-3-oxo-2,3-dihydro-1h-pirazol-4-il) - 5 - (4-isopropylcyclohexane-1-en-1 He also mentioned a pharmacology composer and a group. This compound is smad-1 (smurf-1) without the activity of location-specific regulator, which is very useful in the treatment of pulmonary hypertension, glaucoma and so on.Se refiere a un derivado de carboxamida de formula (I) o una sal farmaceuticamente aceptable del mismo, donde: R1 es alquilo (C3-C6) o cicloalquilo (C3-C6)； R2 es metilo； R3 es alquilo ramificado (C6-C10), alquenilo ramificado (C6-C10), entre otros. Es un compuesto seleccionado: [N-(2-ciclohexil-1,5-dimetil-3-oxo-2,3-dihidro-1H-pirazol-4-il)-5-(4-isopropilciclohex-1-en-1-il)-4-metilisoxazol-3-carboxamida]； entre otros. Tambien se refiere a una composicion farmaceutica y una combinacion. Dicho compuesto modula la actividad del factor regulador de ubiquitinacion de Smad 1 (Smurf-1) siendo util en el tratamiento de hipertension arterial pulmonar, glaucoma, entre otros
