DSOUZA, Anne-Marie,AHMED, Mahbub,PULZ, Robert Alexander,ROONEY, Lisa Ann,SMITH, Nichola,TROXLER, Thomas Josef,BALA, Kamlesh Jagdis,BREARLEY, Andrew,DALE, James,PORTER, David,SANDHAM, David Andrew,SHAW
申请号：
PE0005462017
公开号：
PE14432017A1
申请日:
2015.05.14
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Refers to a carboxamide Derivative of formula (i) or a pharmaceutically acceptable Salt thereof, where R1 is alkyl or cycloalkyl (C3 and C6) (C3 and C6) R2 is Methyl R3 is branched alkyl (C6 C10), alquenilo branched (C6 C10), among others.It is a compound selected: [N - (2 - Cyclohexyl - 1.5 - dimethyl - 3 - oxo 2,3 dihydro - 1h-pyrazol-4-yl) - 5 - (4 - isopropilciclohex - 1 - 1 - il) - 4 - metilisoxazol - 3 - carboxamide], among others. It also relates to a Pharmaceutical Composition and a combination.This Compound modulates the activity of Smad ubiquitination Regulatory factor 1 (Smurf - 1) is useful in the treatment of pulmonary arterial hypertension, glaucoma, among othersSe refiere a un derivado de carboxamida de formula (I) o una sal farmaceuticamente aceptable del mismo, donde: R1 es alquilo (C3-C6) o cicloalquilo (C3-C6) R2 es metilo R3 es alquilo ramificado (C6-C10), alquenilo ramificado (C6-C10), entre otros. Es un compuesto seleccionado: [N-(2-ciclohexil-1,5-dimetil-3-oxo-2,3-dihidro-1H-pirazol-4-il)-5-(4-isopropilciclohex-1-en-1-il)-4-metilisoxazol-3-carboxamida] entre otros. Tambien se refiere a una composicion farmaceutica y una combinacion. Dicho compuesto modula la actividad del factor regulador de ubiquitinacion de Smad 1 (Smurf-1) siendo util en el tratamiento de hipertension arterial pulmonar, glaucoma, entre otros
