Disclosed is a microneedle-coating composition which contains a physiologically active substance (except Japanese encephalitis vaccine antigen), a basic amino acid and an acid and in which the number of moles of the acid per mole of the basic amino acid exceeds 1/(N+1) and is less than 2 [wherein N is the valency of the acid].本發明揭示了一種微針頭塗覆用組成物,其係含有生理活性物質(惟日本腦炎疫苗抗原除外)、鹼性胺基酸及酸,在將酸的價數定為N時,相對於鹼性胺基酸1莫耳,酸的莫耳數超過1/(N+1)且未滿2。