The present invention provides LAMP Constructs comprising specific fragmentsof the LAMP lumenal domain todeliver cancer antigens to immune cells for enhanced processing These LAMPConstructs can be used for the treatment of diseaseand m particular hyperproliferative disorders and/or cancer The LAMPConstructs allow for presentation of properly configured threedimensional epitopes for production of an immune response when administered toa subject The LAMP Constructs can be multivalentmolecules, and/or can be provided as part of a multivalent vaccine containingtwo or more LAMP Constructs The LAMP Constructsas described herem can also be used to generate antibodies when administeredto a non-human vertebrate
