METHOD FOR INDUCING DIFFERENTIATION OF MYELOID-DERIVED SUPPRESSOR CELLS FROM CORD BLOOD CD34 POSITIVE CELLS AND PROLIFERATING SAME, AND USE OF MYELOID-DERIVED SUPPRESSOR CELLS
THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
KIM, Tai Gyu,PARK, Mi Young
申请号：
WO2016KR07912
公开号：
WO2017014561(A1)
申请日:
2016.07.20
申请国别(地区):
世界知识产权组织国际局
年份:
2017
代理人:
摘要：
The present invention relates to a method for inducing differentiation myeloid-derived suppressor cells from cord blood CD34 positive cells and proliferating the same, and a use of the myeloid-derived suppressor cells. More specifically, myeloid-derived suppressor cells are induced to differentiate and proliferated by culturing cord blood CD34 positive cells in the presence of a cytokine cocktail of GM-CSF and SCF, such that myeloid-derived suppressor cells can be mass-produced in vitro, and the myeloid-derived suppressor cells can be used in preventing or treating immunorejection-related diseases such as graft-versus-host disease.
