FORMULATIONS DE SOLUTION INTRAVEINEUSE DE POSACONAZOLE STABILISÉES PAR BÊTA-CYCLODEXTRINE SUBSTITUÉE

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专利权人:

MERCK SHARP & DOHME CORP.

发明人:

申请号：

EP18171672.1

公开号：

EP3391890A1

申请日:

2011.06.24

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention relates to aqueous solutions useful as pharmaceutical compositions of posaconazole for intravenous administration. These compositions include a solubilizing agent, such as a modified β-cyclodextrin in an acidified solution, which can also include a chelating agent such as disodium edetate (EDTA). In clinical trials, a 200 mg posaconazole dose of the selected composition was found to achieve acceptable pharmacokinetic properties.

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