Solution formulation for intravenous injection of posaconazole stabilized by substituted β-cyclodextrin

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专利权人:

メルク・シャープ・エンド・ドーム・コーポレイション

发明人:

ヘイムベシヤー，スーザン・ケイ,モンテイース，デイビツド,ピプキン，ジエイムズ・デイ,ヘイムベシヤー,スーザン・ケイ,モンテイース,デイビツド,ピプキン,ジエイムズ・デイ

申请号：

JP2013518498

公开号：

JP6008849B2

申请日:

2011.06.24

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The present invention relates to aqueous solutions useful as pharmaceutical compositions of posaconazole for intravenous administration. These compositions include a solubilizing agent, such as a modified ²-cyclodextrin in an acidified solution, which can also include a chelating agent such as disodium edetate (EDTA). In clinical trials, a 200 mg posaconazole dose of the selected composition was found to achieve acceptable pharmacokinetic properties.

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中国工程科技知识中心

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