Susan K. Heimbecher,David Monteith,James D. Pipkin
申请号:
US14668683
公开号:
US20150265715A1
申请日:
2015.03.25
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention relates to aqueous solutions useful as pharmaceutical compositions of posaconazole for intravenous administration. These compositions include a solubilizing agent, such as a modified β-cyclodextrin in an acidified solution, which can also include a chelating agent such as disodium edetate (EDTA). In clinical trials, a 200 mg posaconazole dose of the selected composition was found to achieve acceptable pharmacokinetic properties.