POSACONAZOLE INTRAVENOUS SOLUTION FORMULATIONS STABILIZED BY SUBSTITUTED BETA CYCLODEXTRIN

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专利权人:

发明人:

HEIMBECHER SUSAN K,MONTEITH DAVID

申请号：

IN10049/CHENP/2012

公开号：

IN2012CN10049A

申请日:

2012.11.29

申请国别(地区):

IN

年份:

2014

代理人:

摘要：

The present invention relates to aqueous solutions useful as pharmaceutical compositions of posaconazole for intravenous administration. These compositions include a solubilizing agent such as a modified cyclodextrin in an acidified solution which can also include a chelating agent such as disodium edetate (EDTA). In clinical trials a 200 mg posaconazole dose of the selected composition was found to achieve acceptable pharmacokinetic properties.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/