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Derivatives of n-benzo [d] isoxazol-3-yl-amine compounds as inhibitors of mGluR5 receptors, serotonin (5-HT) and noradrenaline and their use in the production of medicines.
专利权人:
GRUENENTHAL GMBH
发明人:
MERLA, BEATRIX,GERLACH, MATTHIAS,SUNDERMANN, CORINNA,JAGUSCH, UTZ-PETER,HENNIES, HAGEN-HEINRICH,OBERBOERSCH, STEFAN,HAURAND, MICHAEL,JOSTOCK, RUTH,REICH, MELANIE
申请号：
ES06761974
公开号：
ES2373684T3
申请日:
2006.06.06
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Medicament containing at least one selected from the group consisting of [1] compound benzo [d] isoxazol-3-ylamide thiophene-2-carboxylic acid [3] benzo [d] isoxazol-3-ylamide acid naphthalen 2-carboxylic acid, [4] benzo [d] isoxazol-3-ylamide adamantan-2-carboxylic acid, [5] benzo [d] isoxazol-3-ylamide cyclohexanoic acid, [6] N-benzo [d] isoxazol -3-yl-2,2-dimethyl-propionamide, [7] N- (4-methoxybenzo [d] isoxazol-3-yl) -2,2-diphenylacetamide, [8] (5-bromobenzo [d] isoxazol- 3-yl) amide ciclopropanoico acid, [9] 3,5-dichloro-N- (6-fluorobenzo [d] isoxazol-3-yl) benzamide, [10] N- (4-aminobenzo [d] isoxazol-3 -yl) -4-nitrobenzamide, [11] (4-aminobenzo [d] isoxazol-3-yl) -amide naphthalen-1-carboxylic acid [12] (4-fluorobenzo [d] isoxazol-3-yl) amide benzo [b] thiophene-2-carboxylic acid, [13] N-benzo [d] isoxazol-3-yl-2-trifluoromethylbenzamide, [14] N-benzo [d] isoxazol-3-yl-3, 4-dichlorobenzamide [15] N-benzo [d] isoxazol-3-yl-2,3-difluorobenzamide, [16] N- (4-dimethylaminobenzo [d] isoxazo l-3-yl) -3-fluorobenzamide, [17] (6-fluorobenzo [d] isoxazol-3-yl) amide thiophene-2-carboxylic acid, [18] N- (6-fluorobenzo [d] isoxazol- 3-yl) -2-methyl-butyramide, [19] N- (6-chloro-benzo [d] isoxazol-3-yl) -2-fluoro-3-trifluoromethylbenzamide, [20] N- (6-chlorobenzo [ d] isoxazol-3-yl) -3-methoxybenzamide, [21] N- (6-bromobenzo [d] isoxazol-3-yl) -4-tert-butylbenzamide, [23] N- (6-bromobenzo [d] isoxazol-3-yl) -2-trifluoromethylbenzamide, [24] (6-bromobenzo [d] isoxazol-3-yl) adamantan-2- amide carboxylic acid, [25] N- (6-bromobenzo [d] isoxazol-3-yl) -2-methyl-butyramide, [26] N- (5-fluorobenzo [d] isoxazol-3-yl) -2-trifluoromethylbenzamide, [27] 3,4-dichloro-N- ( 5-fluorobenzo [d] isoxazol-3-yl) benzamide, [28] N- (5-fluorobenzo [d] isoxazol-3-yl) -2-methylbenzamide, [29] N- (5-bromobenzo [d] isoxazol -3-yl) -2-fluoro-5-trifluoromethyl-benzamide, [30] N- (5-bromobenzo [d] isoxazol-3-yl) -2,4-difluorobenzamide, [31] N- (5-methylbenzo [d] isoxazol-3-yl) -2-trifluoromethylb
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