The invention relates to a novel method for treating or reducing the symptoms of schizophrenia, said method comprising administering to a host in need thereof an effective amount of a compound able to selectively increase the ion flow through KCNQ potassium channels. Furthermore the invention relates to the use ofselective KCNQ potassium channel openers for the preparation of a pharmaceutical composition for treating or reducing the symtoms of schizophrenia and related symptoms, disorders and diseases. Furthermore the invention relates to a method of screening for a compound, which is a selective KCNQ potassium channel opener and which is capable of having an anti-psychotic potential.本發明關於新穎治療或減輕精神分裂症狀的方法,該方法包括施與一需要治療患者一有效量能夠選擇性增加流經KCNQ鉀通道離子流化合物。再者,本發明關於此選定KCNQ鉀通道開放劑製備治療或減輕精神分裂症狀和相關症狀,不適及疾病藥學組成物之應用。除此之外,本發明關於一種篩選特定KCNQ鉀通道開放劑,且能夠具有抗精神病潛力化合物的方法。