Inhibidores de la cisteína proteasa para el tratamiento de enfermedades parasitarias

• 收藏
• 分享

专利权人:

MERCK CANADA INC.

发明人:

ISABEL, ELISE,MELLON, CHRISTOPHE,BEAULIEU, CHRISTIAN

申请号：

ES08853988

公开号：

ES2533875T3

申请日:

2008.11.26

申请国别(地区):

ES

年份:

2015

代理人:

摘要：

A compound selected from: (S) -4,4-dichloro-N - [(S) -cyano- (4-cyano-2-fluoro-benzyl) -methyl] -2 - [(S) -2,2, 2-trifluoro-1- (4-methanesulfonyl-biphenyl-4-yl) - ethylamino] -butyramide [(S) -1-cyano-2- (4-cyano-2-fluoro-phenyl) -ethyl] -amide (S) -4-fluoro-4-methyl-2 - [(S) -2, 2,2-trifluoro-1- (4-methanesulfonyl-biphenyl-4-yl) ethylamino] pentanoate [(R) -1-cyano-2- (4-cyano-2-fluoro-phenyl) -ethyl] -amide (S) -4-fluoro-4-methyl-2 - [(S) -2, 2,2-trifluoro-1- (4-methanesulfonyl-biphenyl-4-yl) ethylamino] pentanoate [2- (2-chloro-4-cyanophenyl) -1-cyanoethyl] -amide (S) -4-fluoro-4-methyl-4 - [(S) -2,2,2 trifluoro-1- (4-methanesulfonyl-biphenyl-4-yl) ethylamino] pentanoate [2- (2-chloro-4-cyanophenyl) -1-cyanoethyl] -amide (S) -2 - [(S) -1- (2-chloro-4-methanesulfonyl-biphenyl -4-yl) -2,2,2-trifluoro-ethylamino] -4-fluoro-4-methyl-pentanoic acid [1-cyano-2- (4-cyano-2-fluoro-phenyl) -ethyl] -amide (S) -2 - [(S) -1 - (- 2-chloro-4-methanesulfonyl- biphenyl-4-yl) -2,2,2-trifluoro-ethylamino] -4-fluoro-4-methyl-pentanoic acid Acid amide 1- {4 - [(S) -1 - ((S) -1 - {[(S) -cyano- (4-cyano-2-fluoro-benzyl) -methyl] -carbamoyl} -2 methyl-propylamino) - 2,2,2-trifluoroethyl] -biphenyl-4-yl} cyclopropanecarboxylic acid (S) -N - [(S) -cyano- (4-cyano-2-fluoro-benzyl) -methyl] -2 - {(S) -1- [4 - ((R) -2,2 difluoro-1-hydroxyethyl) -biphenyl-4-yl] -2,2,2-trifluoro-ethylamino} -3-methyl-butyramide [(R, S) -1-cyano-2- (4-cyano-2-fluoro-phenyl) -ethyl] -amide (S) -4-fluoro-4-methyl-2 - [(S) - 2,2,2-trifluoro-1- (4-methanesulfonyl-biphenyl-4-yl) ethylamino] pentanoate [(S) -1-cyano-2- (4-cyano-2-fluoro-phenyl) -ethyl] -amide (S) -4-fluoro-4-methyl-2 - [(S) -2, 2,2-trifluoro-1- (4-methanesulfinyl-biphenyl-4-yl) ethylamino] pentanoate [(S) -1-cyano-2- (4-cyano-2-fluoro-phenyl) -ethyl] -amide (S) -4-fluoro-4-methyl-2 - [(S) -2, 2,2-trifluoro-1- (4-methylsulfanyl-biphenyl-4-yl) ethylamino] pentanoate [(S) -cyano- (4-cyano-2-fluoro-benzyl) -methyl] -amide (S) -2 - {(S) -1- [4 - ((R) -2,

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/