An agronomic method for the production of vegetables and mushrooms, comprising the steps of: - performing a preventive chemical, physical and pedologic analysis of the soils intended for cultivation, in order to identify their composition, hydrologic characteristics, and verify the absence of pathogens, infesting organisms and pollutants; - selecting among natural seeds and mycelia, not genetically modified, the ones most suitable for the parameters of the soil identified previously; - performing iterated periodic checks on the vegetable, mushroom species, that grow after seeding, in order to detect biotic adversities and/or infestations thereof; - performing at least one plant protection treatment by using active ingredients selected among insecticides, herbicides, acaricides, limacides and fungicides; - near the time of harvest, performing iterated periodic spot checks of the vegetables, mushrooms, in order to measure the residual concentration of active plant protection principles; - upon sampling to assess the residual concentration of active plant protection principles lower than 0.01 mg/kg, harvesting the cultivated vegetables, mushrooms.