An agronomic method for the production of vegetables and mushrooms, includes the steps ofperforming a preventive chemical, physical and pedologic analysis of the soils intended for cultivation, in order to identify their composition, hydrologic characteristics, and verify the absence of pathogens, infesting organisms and pollutants;selecting among natural seeds and mycelia, not genetically modified, the ones most suitable for the parameters of the soil identified previously; andperforming iterated periodic checks on the vegetable, mushroom species, that grow after seeding, in order to detect biotic adversities and/or infestations thereof.The method further includes the steps of performing at least one plant protection treatment by using active ingredients selected among insecticides, herbicides, acaricides, limacides and fungicides;near the time of harvest, performing iterated periodic spot checks of the vegetables, mushrooms, in order to measure the residual concentration of active plant protection principles; andupon sampling to assess the residual concentration of active plant protection principles lower than 0.01 mg/kg, harvesting the cultivated vegetables, mushrooms.