University College Cork-National University of Ireland; Cork
发明人:
申请号：
EP18177686.5
公开号：
EP3581202A1
申请日:
2018.06.14
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
A composition for stabilising a vaccine in a solid dosage format is provided wherein the composition comprises an antioxidant, such as glutathione, a monosaccharide or disaccharide sugar, such as trehalose, a polyol sugar, such as sorbitol, one or more salts, such as magnesium chloride and sodium glutamate, and a vaccine. The composition may also comprise an aqueous soluble polymer, such as polyvinyl alcohol (PVA). A preferred composition comprises 40 mM glutathione, 20% w/v trehalose, 3% w/v sorbitol, 1.5% w/v PVA, 3% w/v magnesium chloride and 3% w/v sodium glutamate. Also provided is a method of stabilising a vaccine in a solid dosage format, the method comprising drying the stabilising composition to provide the vaccine in the solid dosage format. The composition and method may be used to stabilise any suitable vaccine, such as poliovirus, in a solid dosage format, such as microneedle patches.
