S. George Kottayil,Amresh Kumar,Prasanna Sunthankar,Vimal Kavuru
申请号：
US16046476
公开号：
US20180325886A1
申请日:
2018.07.26
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.
