Kottayil, George S.,Kumar, Amresh,Sunthankar, Prasanna,Kavuru, Vimal
申请号:
AU2020201863
公开号:
AU2020201863A1
申请日:
2020.03.13
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
#$%^&*AU2020201863A120200402.pdf#####ABSTRACT A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.