The present application relates to a method of a nitric oxide releasing agent for the preparation of a medicament for the prevention or treatment of VEGFR and/or VEGF inhibition-associated diseases or disorders. The present application also provides a method of preventing or treating a VEGFR and/or VEGF inhibition-associated diseases or disorders, the method comprising administering a prophylactically or therapeutically effective amount of the anitric oxide releasing agent to a subject in need thereof.本申請涉及一氧化氮釋放劑在製備藥物中的用途,所述藥物用於預防或治療與施用VEGFR抑制劑和/或VEGF抑制劑相關的疾病或病症。本申請還提供預防或者治療與施用VEGFR抑制劑和/或VEGF抑制劑相關的疾病或病症的方法,所述方法可包括向有需要的受試者施用預防或治療有效量的一氧化氮釋放劑。