This invention relates to methods and compositions useful for the treatment or prevention of an ophthalmological disease, comprising administration of an effective amount of a PDGF antagonist and a VEGF antagonist to a mammal in need thereof.本發明係關於適用於治療或預防眼科疾病之方法及組合物,其包含向有需要之哺乳動物投與有效量之PDGF拮抗劑及VEGF拮抗劑。