To provide a novel nucleic acid aptamer for a vascular endothelial growth factor receptor, said nucleic acid aptamer being useful for the diagnosis and treatment of various diseases associated with VEGFs that can regulate angiogenesis and receptors for the VEGFs, e.g., tumor angiogenesis, diabetic retina and chronic rheumatoid arthritis. A nucleic acid aptamer characterized by comprising a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 5, and also characterized by being capable of bonding to a human VEGF receptor specifically. In a preferred embodiment of the nucleic acid aptamer, a primer recognition sequence, a fluorescent label, or a biotin molecule, an avidin molecule, a streptavidin molecule or other specific binding tag peptide may be linked to the 5- or 3-terminal of the nucleic acid aptamer for the purpose of making it possible to detect the nucleic acid aptamer easily.提供一種有用於與控制血管新生之VEGF與其受體有關的各種疾病,例如,腫瘤血管新生、糖尿病性視網膜症以及慢性關節風濕症等疾病的診斷及治療之,針對血管內皮生長因子受體的新穎核酸適體。一種核酸適體,其特徵係包含序列編號1~5所示核苷酸序列,並且特異性地對人類VEGF受體結合。較佳之態樣中,為了容易檢測出上述核酸適體,其5’端或3’端也可以與引子識別序列、螢光標識、生物素、抗生物素蛋白質或鏈親和素或其他特異性結合標籤肽連結。
