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NUCLEIC ACID APTAMER CAPABLE OF BONDING TO VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR
专利权人:
发明人:
申请号:
EP16772732.0
公开号:
EP3279325A1
申请日:
2016.03.28
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
[Problem] To provide a novel nucleic acid aptamer for a vascular endothelial growth factor receptor, said nucleic acid aptamer being useful for the diagnosis and treatment of various diseases associated with VEGFs that can regulate angiogenesis and receptors for the VEGFs, e.g., tumor angiogenesis, diabetic retina and chronic rheumatoid arthritis. [Solution] A nucleic acid aptamer characterized by comprising a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 5, and also characterized by being capable of bonding to a human VEGF receptor specifically. In a preferred embodiment of the nucleic acid aptamer, a primer recognition sequence, a fluorescent label, or a biotin molecule, an avidin molecule, a streptavidin molecule or other specific binding tag peptide may be linked to the 5- or 3-terminal of the nucleic acid aptamer for the purpose of making it possible to detect the nucleic acid aptamer easily.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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