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Human monoclonal antibody neutralizing vascular endothelial growth factor receptor and use thereof
专利权人:
Jin-San Yoo
发明人:
Jin-San Yoo,Weon-Sup Lee,Sang-Ryeol Shim,Mi-Hee Park,Jeong-Eun Kang,Do-Yun Kim,Joon Chul Lee,Dong-Heon Lee,Too-Hyon Cho,Sam-Sook Sul,Young-Guen Kwon,Bo-Jeong Pyun,Kwi-Hwa Kim,Chae-Ok Yun,Nahm-Ju Kim,J
申请号:
US12664226
公开号:
US09150650B2
申请日:
2007.06.26
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention relates to human monoclonal antibodies neutralizing vascular endothelial growth factor receptor and the use thereof. More specifically, relates to human ScFv molecules neutralizing vascular endothelial growth factor receptor, and a composition for inhibiting angiogenesis and a composition for treating cancer, which contain the human ScFv molecules. The disclosed monoclonal antibody neutralizing vascular endothelial growth factor receptor shows excellent neutralizing ability in living cells, compared to that of a commercially available antibody against vascular endothelial growth factor receptor, and shows the ability to neutralize vascular endothelial growth factor receptor not only in humans, but also in mice and rats. Thus, the monoclonal antibody will be useful in anticancer studies and will be highly effective in cancer treatment.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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