The invention provides a new type of a capsid protein VP1 of human enterovirus 71, named as MEL701-VP1 and functional/ structural variants thereof, which is used for protection against enterovirus. The transgenic animal producing the protein, the composition comprising the protein and the method for production thereof are also provided.本發明提供人類腸病毒71型之一種新穎類型鞘蛋白,稱為MEL701-VP1,以及其功能/結構變體,其係用於保護對抗腸病毒。亦提供生產該蛋白之轉基因動物,包含該蛋白之組合物,以及其製備方法。