The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.本發明揭示且請求專利類病毒顆粒(VLP),其可表現及/或含有得自可能爆發大流行的病毒之季節性流行性感冒(流感)病毒蛋白質、禽流感病毒蛋白質及/或流感病毒蛋白質。本發明包括包含該蛋白質之載體構築體、包含該構築體之細胞、包含本發明之VLP之調配物及疫苗。本發明也包括製造VLP及將VLP投予脊椎動物之方法,包括對季節性流感及禽流感或至少一種症狀誘生實質免疫力之方法。
