Refers to compounds derived from pirimido - [4,5-b] quinolin-1 - 4.5 - (3H, 10h) - dione of formula (i) wherein R1, R2, R3, R4 and R5 are as defined in the specification. Preferred compounds are: 2 - methyl - 3 - 10 - cyclobutyl phenyl - pirimido - [4,5-b] - quinoline - 4.5 (3H, 10h) - dione 10 - Allyl - 2 - isopropyl - 3 - phenyl - pirimido - [4,5-b] - quinoline - 4.5 (3H, 10h) - dione among others.It also relates to a Pharmaceutical composition. These compounds are suppressors of missense mutations being useful in the treatment of Hemophilia A and B, cystic fibrosisSE REFIERE A COMPUESTOS DERIVADOS DE PIRIMIDO-[4,5-b]-QUINOLIN-4,5(3H,10H)-DIONA DE FORMULA (I) DONDE R1, R2, R3, R4 Y R5 SON COMO SE DEFINEN EN LA MEMORIA DESCRIPTIVA. SON COMPUESTOS PREFERIDOS: 2-CICLOBUTIL-10-METIL-3-FENIL-PIRIMIDO-[4,5-b]-QUINOLINA-4,5(3H,10H)-DIONA 10-ALIL-2-ISOPROPIL-3-FENIL-PIRIMIDO-[4,5-b]-QUINOLINA-4,5(3H,10H)-DIONA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON SUPRESORES DE MUTACIONES SIN SENTIDO SIENDO UTILES EN EL TRATAMIENTO DE HEMOFILIA A Y B, FIBROSIS QUISTICA
