LEE, CHEWAH,HENDERSON, JACLYN LOUISE,GREEN, MICHAEL ERIC,GRAY, DAVID LAWRENCE FIRMAN,EFREMOV, IVAN VIKTOROVICH,ZHANG, LEI,DAVOREN, JENNIFER ELIZABETH,BRODNEY, MICHAEL AARON,ROGERS, BRUCE NELSEN,ONEIL,
申请号：
PE0026142015
公开号：
PE06642016A1
申请日:
2014.06.13
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
Refers to compounds Pyridine Derivatives of formula (i) where T1, T2, T3, T4, L1, Q1, R1, R2, R3 and R4 are as defined in the description. Preferred compounds are: (-) - 6 - (4 - [(3 - ciclopropilpiridin - 2 - il) oxy] - 2-methylphenyl} - 1.5 - dimetilpirimidin - 2,4 (1H, 3H) - dione (-) - 6 - (4 - [(3 - Chloro - 5 - fluoropiridin - 2 - il) oxy] - 2-methylphenyl} - 1.5 - dimetilpirimidin - 2,4 (1H, 3H) - dione, among others.It also relates to a Pharmaceutical composition. These compounds are being dopamine D1 receptor agonists useful in the treatment of schizophrenia, cognitive impairment, Autism Spectrum Disorder, dementia, Parkinsons diseaseSE REFIERE A COMPUESTOS DERIVADOS DE PIRIDINA DE FORMULA (I) DONDE T1, T2, T3, T4, L1, Q1, R1, R2, R3 Y R4 SON TAL COMO SE DEFINEN EN LA DESCRIPCION. SON COMPUESTOS PREFERIDOS: (-)-6-{4-[(3-CICLOPROPILPIRIDIN-2-IL)OXI]-2-METILFENIL}-1,5-DIMETILPIRIMIDIN-2,4(1H,3H)-DIONA (-)-6-{4-[(3-CLORO-5-FLUOROPIRIDIN-2-IL)OXI]-2-METILFENIL}-1,5-DIMETILPIRIMIDIN-2,4(1H,3H)-DIONA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR D1 DE DOPAMINA SIENDO UTILES EN EL TRATAMIENTO DE ESQUIZOFRENIA, DISCAPACIDAD COGNITIVA, TRASTORNO DEL ESPECTRO DE AUTISMO, DEMENCIA, ENFERMEDAD DE PARKINSON
